Atrial natriuretic factor and transgenic mice.
نویسندگان
چکیده
منابع مشابه
Atrial natriuretic factor and transgenic mice.
Atrial natriuretic factor (ANF) is a peptide hormone that induces potent but transient hypotensive and natriuretic responses on short-term administration. The role of the hormone in long-term cardiovascular regulation has remained elusive in part because of the temporal limitations of long-term infusion models and the extremely short half-life of the molecule in vivo. To circumvent these tempor...
متن کاملHemodynamics in transgenic mice with overexpression of atrial natriuretic factor.
The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared with their nontransgenic siblings. Transgenic animals exhibited immunoreactive AN...
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The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared with their nontransgenic siblings. Transgenic animals exhibited immunoreactive AN...
متن کاملAtrial natriuretic factor.
A short and up-to-date review on the great advances made in the field of the atrial natriuretic factor (ANF) is presented. All the short active peptides (up to 33 AA) isolated after purification of atrial homogenates have the same core of 23 amino acids (Ser 103-ARG 125). The ANF liberated in the medium of cultures of rat atrial cardiocytes is the 26 amino acid Arg 101-Tyr 126. Cloning of the c...
متن کاملAtrial natriuretic factor and the atrial function.
Accessible online at: http://BioMedNet.com/karger Dear Sir, I read with interest the report by Takeichi et al. [1] on the relationship between left atrial function and plasma levels of atrial natriuretic peptide in patients with various types of heart disease. I would like to make three comments. First, the term atrial natriuretic factor (ANF) is preferable to the term atrial natriuretic peptid...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1993
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.22.4.634